It isnt (yet) considered a drug that can help improve healthspan or lifespan, and so you may need to find a forward thinking doctor if you want it prescribed for general health. (2019). David Sinclair, Ph.D., Harvard professor of genetics, . 2019 (November) A Japanese study into the safety of oral NMN showed no negative changes to blood biomarkers and other health measurements after doses of NMN at 100, 250, and 500. At 37m 20s of the podcast, David shares an anecdote about an early pioneer in the field of aging called Denham Harman. However with spermidine, it is possible to get large amounts from day to day foods. This precursor is a naturally occurring compound that is found in small amounts in fruits and vegetables such as broccoli, cucumber, avocado and edamame. Sinclair doesn't go into great detail about what to eat, but does touch on some key points: Eat less meat, eat more plants. I dont believe in exercise that is not strenuous, says Dr. Sinclair, who adds that people should try high-intensity interval training three times a week, working out at 85 percent of their maximum heart rate for about two minutes or until they are exhausted. We looked at what he does to stay youthful, and what supplements David Sinclair takes. The less time you will spend with disease symptoms. 1. Micronutrient rich smoothies - Rhonda uses these as a core method of increasing her raw vegetable intake, enriching her diet with micronutrients and pre-biotic fibre. First well look at the sirtuin activator David takes; Resveratrol. He doesnt mention a specific dose, but just says that he takes 1 large pill daily. Dr. Sinclair urges people to avoid alcohol as much as possible because of its link to cancer. Dr. Sinclair takes 1 gram of resveratrol in the morning mixed in yogurt. Vitamin D is an essential micronutrient, and is thought to exercise significant effect on at least 200 of our genes21A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution Ramagopalan et al. If you remember the hype some years ago around red wine being healthy, part of that was due to it containing resveratrol (allbeit in tiny amounts). Then similarly a more recent European Food Safety Authority document discusses stability (, Lower blood glucose, triglycerides and fasting insulin in patients with type 2 diabetes, Activate the AMPK pathway which, among other things, increases cellular cleanup (autophagy), David is a longevity researcher who is certainly aging gracefully. Resveratrol is light sensitive, and when left exposed to light it turns brown. Yes, David Sinclair is legit. Specifically called spermidine trihydrochloride (spermidine 3HCL), with the hydrochloride (HCL) attachment stabilizing it for transport and storage. (2004). More on that below. At which point it would come down to a decision whether the benefits of metformin/resveratrol outweigh the (potential) small impact on recovery. But as you can imagine, it's an unpopular strategy for humanshence the excitement about resveratrol. Whilst SpermidineLIFE is composed of a standardized wheat germ extract, which itself contains spermidine. Check it out on Amazon. As with NMN, we don't recommend buying resveratrol off of Amazon. (2017). After taking the B12/Folate supplement for a few months, in February 2020 David got some blood tests done, and found his B12 levels were double the recommended maximum so he stopped taking it (source: Davids Facebook post). Fast intermittently. (2016). Because we were running late, he asked his wife to send . 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