Before Thrombocytopenia is a commonly-reported side effect of COVID-19 vaccines, as are blood clots, strokes and lethal heart attacks all of which are pointing toward spike proteins causing vascular damage. Once it gets in the blood, it accumulates in a number of tissues such as the spleen, the bone marrow, the liver, the adrenal glands. Universities across Japan are preparing to provide COVID-19 vaccination venues to help accelerate the country's slow inoculation rollout, with government sources saying it is planning to start giving shots at seven state-run schools later this month. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal As of August 23, 2021, the Pfizer-BioNTech inoculation is now approved under the brand name Comirnaty. And of particular concern for me is it accumulates in the ovaries, in quite high concentrations.. Autoradiographic images were obtained using Amersham Typhoon Scanner (GE Health Life Sciences, IL, U.S.A.). The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. It can cause damage in our body if it gets into circulation The spike protein on its own is almost entirely responsible for the damage to the cardiovascular system, if it gets into circulation.. The European Medicine Agency (EMA) is an agency of the European Union (EU) in charge of the Evaluation and Supervison of Medicinal Products. Likewise, research within thescientific community also reveals various cardiovascular and heart problems, bleeding, and clotting when studying the disease in humans. In what organs can you find the vaccine? (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: 8.5. The Comirnaty/Pfizer-BioNTech Fact Sheet for Healthcare Providers Administering Vaccine clearly states that pre-authorization Pfizer-BioNTech vaccine and the Comirnaty vaccine are equivalent. Dr. Byram W. Bridle, Ph.D. says the he and several colleagues gained access to a first-of-its-kind "biodistribution" study out of Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer-BioNTech cause the production of spike proteins that more often than not get into the As expected with an mRNA product, the luciferase expression was transient and decreased over time. When administered, COVID-19 vaccines are injected into the shoulder musclenot into the blood. Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic effects, while angiotensin (17) has opposing effects In addition, angiotensin II increases cytoplasmic and mitochondrial ROS generation leading to oxidative stress. As we reported last June 14, Bridle received a copy of a Japanese biodistribution study, which had been withheld from the public, as a result of a freedom of information request made to the Japanese government for data from Pfizer. A biodistribution study of the Pfizer Covid-19 injection suggests a suspension of the use of mRNA 'Vaccines' is urgently required and blood donor organisations need to take a long hard look at their policies surrounding the acceptance of donations of blood from people who have received an mRNA based Covid-19 injection. Change), You are commenting using your Twitter account. Shockingly, according to Bridle, the COVID-19 vaccine is different from traditional vaccines. This analysis is not usually conducted on ex vivo transduced cells. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Why are these questions surfacing now? Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. This is about as diabolical as it gets. They significantly increase your risk of death, in some cases raising mortality by 50 times compared to people who do not have these conditions. If the damage is serious enough, uncontrolled cell death can occur, which in turn leaks mitochondrial DNA (mtDNA) into your bloodstream.13, Aside from being detected in cases involving acute tissue injury, heart attack and sepsis, freely circulating mtDNA has also been shown to contribute to a number of chronic diseases, including systemic inflammatory response syndrome or SIRS, heart disease, liver failure, HIV infection, rheumatoid arthritis and certain cancers.14 As explained in COVID-19: A Mitochondrial Perspective:15. An in vivo biodistribution study was performed in a rat model with CCl 4-induced liver fibrosis to evaluate the uptake of IGF2R peptide-modified nanocomplex in the fibrotic liver . . When that happens, it can cause platelets to clump together, resulting in blood clots, and/or cause abnormal bleeding, Pfizer documents submitted to the European Medicines Agency also show the company failed to follow industry-standard quality management practices during preclinical toxicology studies and that key studies did not meet good laboratory practice standards. Human organ radiation dosimetry is shown in Table 2. Pfizer's now infamous biodistribution study that was part of a pharmacokinetic package done for the Japanese government found that the LNP's go everywhere and anywhere, with special affinity for the liver, spleen, and ovaries. That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. Blood clots are a common result, and can occur either because the platelets clump together in response to the vessel wall damage, or because your anticlotting mechanism has been compromised. Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. According to Bridle, the discovery also has implications for breastfeeding infants and severe consequences for people for whom the SARS-CoV-2 virus is not a high-risk pathogen, including all children. 2021 Sep 8;22(18):9705. doi: 10.3390/ijms22189705. We wont know the final answers to many questions concerning the mRNA vaccines until at least 2022 or perhaps longer. Characteristics of Extracellular Vesicles and Preclinical Testing Considerations Prior to Clinical Applications. Keywords: The spike protein also travel to your heart, brain and lungs, where bleeding and or blood clots can occur as a result, and is expelled in breast milk. Guidelines on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. eCollection 2015. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. HHS Vulnerability Disclosure, Help You are not transferring antibodies. Our democracy no longer represents the people. In Japan, 10 fatal cases (five men and women) have been reported to date. This false claim originated from: viral social media post. 2021 The Japanese Society for Regenerative Medicine. 2011 Oct;17(10):881-90. doi: 10.1089/acm.2010.0481. Learn more 208-391-4000 As questions intensify surrounding the true origins of SARS-CoV-2, the devastating discovery that spike proteins reach the bloodstream leaves wide open the door for many other legitimate questions about the long-term safety of COVID-19 vaccinesfor example, with it accumulating in the ovaries, will we be rendering some young people infertile?Bridle concluded: We made a big mistake; we didnt realize it until now. Radioactivity was detected in most tissues from the first time point (0.25 h) and results support that injections site and the liver are the major sites of distribution. Bridle also cites recent research showing the spike protein remained in the bloodstream of humans for 29 days. Very often, the damage is caused by the immune system going on the attack, damaging blood vessel walls, and removing several of the anti-clotting mechanisms. The end result can be lethal, and this chain of events is exactly what these COVID-19 vaccines are setting into motion. Pfizer - Confidential Covid-19 Vaccine Biodistribution report. In this work, we have confirmed results in the literature and . 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. According to Kendrick, all of them have two things in common:12. Future Perspectives for Factor V Deficiency Using Recombinant and Advanced Therapies. -. Why the confusion? Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. Pingback: 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy. Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. eCollection 2020 Sep 11. I thought this would be an easy blog to write, cut and dry. Methods This is a . Methods: This is a retrospective single-center study in 23 patients with COVID-19-induced ARDS. You can also boost your sulfate by taking Epsom salt baths. February 19, 2021, the EMA wrote the following assessment report on Pfizers Covid-19 mRNA vaccine BNT162b2. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018, Implementation status of clinical biodistribution, Implementation status of clinical biodistribution by formulation in locally administered product group as, Trends of cell quantification using Alu-qPCR methods. My intent is to bring you facts, not conjecture or opinion. SARS-CoV-2 MRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of Pharmacokinetic Study. Regulatory-Compliant Validation of a Highly Sensitive qPCR for Biodistribution Assessment of Hemophilia A Patient Cells. We never knew the spike protein itself was a toxin and was a pathogenic protein. doi: 10.1371/journal.pone.0135389. In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. Biodistribution. The Japanese biodistribution study results are consistent with Pfizer's that was submitted to the European Medicines Agency (EMA) in February 2021. Its past time to #RevoketheEUA https://t.co/ZdeHCKXyPb, BREAKING: Dr. Byram Bridle sent me his report: 'Why Parents, Teens, and Children Should Question the COVID-19 Vaccine'He's an Associate Professor of Viral Immunology at the University of Guelph who brought attention to the Pfizer Japanese study. Essentially, the assumption behind COVID-19 vaccines is their ability to enable the cells in our bodies to produce spike protein. Japanese government and Pfizer biodistribution study shows 75% of mRNA travels from injection site into blood and distributed into organs and across brain-blood barrier Trying to post again as original post was removed by automod for unknown reasons. Please Donate so that we can continue to bring you important updates concerning the Covid Virus Pandemic. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called "the Bio-Distribution Study." The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. Support responsible news and fact-based information today! Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chdeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. However, while the spike protein found in the virus is bad, the spike protein your body produces in response to the vaccine is far worse. We thought the spike protein was a great target antigen; we never knew it was a toxin. Apart from its role in energy production, mitochondria are crucial for innate immunity, reactive oxygen species (ROS) generation, and apoptosis; all of these are important in COVID-19 pathogenesis. See this image and copyright information in PMC. Is there a difference between the spike protein in the virus itself and the spike protein in the vaccines in terms of effects on the body described here? Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. *, o LNP=LipoNanoParticle which carries the mRNA, o LC-MS/MS is liquid chromatography with tandem mass spectrometry. in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. Well, back in May 2021, I, along with some international colleagues, looked at a document that Pfizer had submitted to the Japanese health regulatory agency. After spending 20 hours of research, I found there are no animal biodistribution studies of mRNA vaccines done by Pfizer, Moderna, or J and J published on an internet search. We do not have all the animal or clinical data needed to completely evaluate long term safety of the mRNA vaccines. A reduction in platelet count, known as thrombocytopenia, is a reliable sign that blood clots are forming in your system, as the platelets are being used up in the process. Using mRNA programmed to produce luciferase protein, as well as mRNA tagged with a radioactive label, Pfizer showed that the majority of the mRNA initially remain near the injection site, but within hours become widely distributed within the body.9. government site. Spike protein does not attack anything, it only aims to activate the immune response, it is not the same as coronavirus spike protein and after vaccination, it is created in a dose 100 thousand times lower than in viral infection. Any objections based on the experimental status of this vaccine are now moot. When an immune response is launched against the spike protein, the virus stops infecting the body. Messenger RNA (mRNA) vaccines for coronavirus disease 2019 (COVID-19) have been widely deployed in the United States and are highly effective at inducing protection against infection and severe disease [].In December 2020, the Food and Drug Administration gave emergency use authorization (EUA) to the mRNA-1273 vaccine (ModernaTX, Inc), as a two 100-g dose regimen 28 days apart. Avoid all vegetable oils and processed foods. It is true that some of experiments looked at the distribution of lipid nanoparticles containing an mRNA coding for Luciferase, a protein that exhibits bioluminescence allowing for visualization where the mRNA ended up. Sunlight also has other benefits besides making vitamin D. Use time-restricted eating and eat all your meals for the day within a six- to eight-hour window. Not so. The signal decreased slowly during the first 72 hours and after 6 and 9 days the signals were further weakened to approximately levels of 18 and 7 times the signals obtained from animals injected with buffer control. This does not mean the animal studies were not done. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. Metabolomic studies suggest that SARS-CoV-2 inhibits mitophagy. Your body for some reason starts to attack the lining of your blood vessels, thereby causing damage and inflammation The why can differ from one case to another, but in all cases, your immune system identifies something foreign in the lining of the blood vessel, causing it to attack. Federal government websites often end in .gov or .mil. Assessments of shedding can be utilized . This is important to understand. To do that, you need to become metabolically flexible and optimize your diet. No traditional pharmacokinetic or biodistribution studies have been performed with the vaccine candidate BNT162b2. Pfizer report_Japanese government.pdf Report ; Share. "The results of this leaked Pfizer study tracing the biodistribution of the vaccine mRNA are not surprising, but the implications are terrifying," Stephanie Seneff, a senior research scientist. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. The "Japanese biodistribution study," referenced in the online article appears to be a Japanese translation of a Pfizer toxicology and biodistribution study, which shows nothing like what is being claimed. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of MRNA-1273 Vaccine Recipients. https://www.pmda.go.jp/files/000205400.pdf, Basu J., Assaf B.T., Bertram T.A., Rao M. Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms. Bridle cites research showing that laboratory animals injected with purified spike protein from SARS-CoV-2 straight into their bloodstream developed cardiovascular problems and brain damage. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. A biodistribution study of the Pfizer Covid-19 injection suggests a suspension of the use of mRNA 'Vaccines' is urgently required and blood donor organisations need to take a long hard look at their policies surrounding the acceptance of donations of blood from people who have received an mRNA based Covid-19 injection. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. . The site is secure. Genotoxicity of 1,3-butadiene and its epoxy intermediates. 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